The Electronic Frontier Foundation (EFF) offers a terrific suggestion for a New Year's resolution that you might actually have a decent chance of keeping: enabling full disk encryption on all of your computers.
Full disk encryption means that if your computer's hard drive falls into the wrong hands – because of theft, loss, or other causes – it remains unreadable until the correct "passphrase" is entered. If, for example, you lose your laptop full of sensitive client data while traveling, you can rest easy knowing that the data on your laptop is protected from prying eyes thanks to the digital vault full disk encryption provides.
Aside from loss and theft, full disk encryption offers the benefit of protecting your data from prying eyes at the U.S. border.
If you're not already using full disk encryption, you should be. The EFF offers suggestions for tools that can be used for full disk encryption in the full article on bringing in 2012 with full disk encryption.